TREATMENT OF EXPERIMENTAL COLITIS BY MODULATING MICROBIOTA AND EICOSANOIDS Effects of probiotics, prebiotics and leukotriene antagonist
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Role of Fatty Acids in the Resolution of Autoimmune and Inflammatory Diseases
The main role of fatty acids is focused on serving as major substrates for energy production; however, fatty acids are also involved in the formation of cellular structures as well as in the transmission of cellular signals. Among the multiple functions attributed to fatty acids are their anti-inflammatory properties. This important characteristic has been applied in the prevention, attenuation...
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Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis (UC), are complex disorders characterized by chronic, local and systemic inflammation and spontaneously relapsing course. The causes of these diseases are unknown, however they display genetic and environmental components and appear to be immunologically mediated in part by enteric microbiota (Baumgart & Carding...
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The short chain fatty acids (SCFAs) acetate (C(2)), propionate (C(3)) and butyrate (C(4)) are the main metabolic products of anaerobic bacteria fermentation in the intestine. In addition to their important role as fuel for intestinal epithelial cells, SCFAs modulate different processes in the gastrointestinal (GI) tract such as electrolyte and water absorption. These fatty acids have been recog...
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The importance of the mammalian intestinal microbiota to human health has been intensely studied over the past few years. It is now clear that the interactions between human hosts and their associated microbial communities need to be characterized in molecular detail if we are to truly understand human physiology. Additionally, the study of such host-microbe interactions is likely to provide us...
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Aging is considered the major risk factor for cancer, one of the most important mortality causes in the western world. Inflammaging, a state of chronic, low-level systemic inflammation, is a pervasive feature of human aging. Chronic inflammation increases cancer risk and affects all cancer stages, triggering the initial genetic mutation or epigenetic mechanism, promoting cancer initiation, prog...
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